Schrödinger 2025 revenue rises 23% to $255.9 million; net loss narrows to $103.3 million
Schrödinger reported fourth-quarter and full-year 2025 results, with full-year total revenue up 23.3% and net loss narrowing from $187.1 million to $103.3 million. Fourth-quarter total revenue fell 1.2%, and the company said it is accelerating a shift to ratable hosted software revenue that it expects to reduce reported software revenue in the short to medium term.
Key points
- Full-year 2025 total revenue was $255.9 million, up 23.3%; software revenue was $199.5 million, up 10.6%.
- Fourth-quarter 2025 total revenue was $87.2 million, down 1.2%; fourth-quarter net income was $32.5 million versus a net loss of $40.2 million a year earlier.
- 2026 outlook calls for software ACV of $218 million to $228 million and drug discovery revenue of $55 million to $65 million.
- The company targets positive adjusted EBITDA by the end of 2028.
The filing
Written by AI on Nov 8, 2026, 6:56 AM ET, from this filing only. Written later: this filing was briefed after the fact, when past filings were added to the site, so the brief may be read with hindsight; the filing itself is the record of what was known on February 25, 2026.
Briefs are written by AI from the filing text and can contain mistakes — open the filing before acting on anything. Impact (1-5) and tone are the AI's reading of the filing for shareholders, not a price forecast. Not investment advice.