Alnylam Q2 net product revenue rises 64% to $672 million; raises 2025 guidance
Alnylam reported second quarter 2025 total net product revenues of $672 million, up 64% from a year earlier, and raised its full-year 2025 total net product revenue guidance to $2,650 million to $2,800 million from $2,050 million to $2,250 million. The company also posted a GAAP loss from operations of $16.2 million, compared with income of $48.6 million a year earlier, and a GAAP net loss of $0.51 per share versus $0.13 in the prior-year quarter.
Key points
- Q2 2025 total revenues were $773.7 million, up 17% from $659.8 million in Q2 2024
- AMVUTTRA net product revenues were $492 million, up 114%; total TTR net product revenues were $544 million, up 77%
- GAAP loss from operations was $16.2 million, versus income of $48.6 million; non-GAAP income from operations fell 31% to $95.5 million
- Cost of goods sold rose to $142.0 million from $67.3 million, and GAAP SG&A expenses rose 30% to $323.3 million
The filing
Written by AI on Nov 8, 2026, 12:42 AM ET, from this filing only. Written later: this filing was briefed after the fact, when past filings were added to the site, so the brief may be read with hindsight; the filing itself is the record of what was known on July 31, 2025.
Briefs are written by AI from the filing text and can contain mistakes — open the filing before acting on anything. Impact (1-5) and tone are the AI's reading of the filing for shareholders, not a price forecast. Not investment advice.