Protagonist Therapeutics, Inc. (PTGX)

Nasdaq Health Care Biotechnology S&P SmallCap 600
$132.04
-3.22 (-2.38%)
Close of Nov 06, 2026 · end-of-day data
SMA 50SMA 2005Y/10Y use weekly candles (10/40-week averages)

Performance

price return
1W-8.8%
1M-5.6%
3M-12.0%
6M+32.9%
YTD+51.2%
1Y+69.5%
3Y+773.9%
5Y+323.8%

Key statistics

Full financials →
Market cap$8.6B
P/E (TTM)28.0
EPS (TTM, diluted)$4.71
P/S15.62
P/B7.94
EV / EBITDA25.0
Revenue (TTM)$552.00M
Revenue growth+163.7%
Net margin62.0%
ROE31.5%
Debt / equity0.01
FCF yield1.3%
Dividend yield—
Payout ratio—
Beta (1Y)0.93
Volatility (1Y)40.0%
52-week range$76.70 – $160.81
Avg volume (50D)708.19K

Revenue & net income — last 8 quarters

Statements →
Nov 5, 4:19 PM ET

Protagonist Therapeutics Reports Third Quarter 2026 Financial Results

Positive earnings 2.02

Protagonist Therapeutics reported third quarter 2026 financial results, highlighted by net income of $220.0 million and license and collaboration revenue of $274.4 million, driven by partner payments following FDA approval of MIMRYLO. Cash, cash equivalents, and marketable securities reached $834.6 million as of September 30, 2026. The company also announced a $300 million share repurchase program authorized in September 2026.

  • Net income for the third quarter of 2026 was $220.0 million, or $3.07 per diluted share, compared to a net loss of $39.3 million, or $0.62 per diluted share, for the third quarter of 2025.
  • License and collaboration revenue reached $274.4 million for the third quarter of 2026, primarily driven by $266.6 million in proportional recognition from Takeda following the FDA approval of MIMRYLO.
  • Cash, cash equivalents, and marketable securities totaled $834.6 million as of September 30, 2026.
  • The Board of Directors authorized a $300 million share repurchase program announced on September 8, 2026.
Read the filing on SEC.gov ↗
Aug 5, 4:11 PM ET

Protagonist posts Q2 net income of $162.8 million versus year-earlier loss of $34.8 million

Positive earnings Written later 2.027.01

Protagonist Therapeutics reported net income of $162.8 million for the quarter ended June 30, 2026, compared with a net loss of $34.8 million a year earlier. Most of the quarter's $213.5 million in license and collaboration revenue came from $192.4 million recognized from the Takeda opt-out payment, so the result reflects a large one-time-style accounting benefit rather than the ongoing run rate. The company also said it expects research and development expense to rise significantly in the second half of 2026.

  • Q2 2026 license and collaboration revenue was $213.5 million, versus $5.5 million in Q2 2025; $192.4 million relates to the Takeda opt-out payment.
  • Q2 2026 net income was $162.8 million, or $2.29 per diluted share, versus a net loss of $34.8 million, or $0.55 per share, a year earlier.
  • R&D expense was $42.1 million in Q2 2026, up from $37.0 million, and the company expects R&D expense to increase significantly in the second half of 2026.
  • Cash, cash equivalents and marketable securities were $849.5 million at June 30, 2026, up from $646.0 million at December 31, 2025; rusfertide has an FDA PDUFA goal date in August 2026.
Read the filing on SEC.gov ↗
Jun 18, 4:30 PM ET

Protagonist Therapeutics stockholders approve 2026 Equity Incentive Plan and elect two directors

Neutral shareholder Written later 5.025.07

At its annual meeting, Protagonist Therapeutics stockholders approved the company's 2026 Equity Incentive Plan, which replaces the 2016 plan and adds 650,000 new shares for future awards. Stockholders also re-elected two Class I directors and approved the other proposals, including a non-binding say-on-pay vote and the ratification of Ernst & Young LLP as auditor.

  • 2026 Equity Incentive Plan approved, adding 650,000 new shares plus returned shares from the 2016 plan
  • Dinesh V. Patel, Ph.D., received 48,714,702 votes for and Lewis T. "Rusty" Williams, M.D., Ph.D., received 45,371,193 votes for
  • Non-binding say-on-pay proposal approved with 53,412,559 votes for and 3,164,702 against
  • Ernst & Young LLP ratified as independent registered public accounting firm for fiscal year ending December 31, 2026
Read the filing on SEC.gov ↗
May 5, 4:08 PM ET

Protagonist swings to $3.8 million Q1 net income on $50 million ICOTYDE milestone

Positive earnings Written later 2.02

Protagonist reported first-quarter 2026 results, with net income of $3.8 million ($0.05 per diluted share) compared with a net loss of $11.7 million ($0.19 per share) a year earlier. Revenue rose to $56.4 million from $28.3 million, mainly due to a $50.0 million milestone from Johnson & Johnson after the FDA approved ICOTYDE, so shareholders should note that the profit depends heavily on this one-time payment while R&D spending also increased.

  • Net income of $3.8 million, or $0.05 per diluted share, versus a net loss of $11.7 million, or $0.19 per share, in Q1 2025
  • License and collaboration revenue of $56.4 million, including a $50.0 million milestone from Johnson & Johnson tied to FDA approval of ICOTYDE in March 2026
  • R&D expense rose to $46.7 million from $35.9 million, driven mainly by the PN-881 Phase 1 study and discovery research
  • Cash, cash equivalents and marketable securities were $620.3 million at March 31, 2026, down from $646.0 million at December 31, 2025
Read the filing on SEC.gov ↗

Briefs are written by AI from the filing text (each brief's own page names the model) and can contain mistakes — open the filing before acting on anything. Impact (1-5) and tone are the model's reading of the filing for shareholders, not a price forecast. Not investment advice.

Recent SEC filings

EDGAR ↗

Famous investors who own PTGX

All investors →
InvestorValue% of portfolioLast quarter
Stanley Druckenmiller Duquesne Family Office $25.61M0.49% Added
Ray Dalio Bridgewater Associates $1.14M0.00% Added

From each investor's latest 13F filing (Q2 2026); positions are as of the quarter end and filed up to 45 days later.

Insider transactions

All insider trades →
DateInsiderTypeSharesPriceValue
Sep 30Ali Asif
Chief Financial Officer
Sell 10b5-158.63K$141.78$8.31M

Prices are end-of-day and split-adjusted. Financial data from Protagonist Therapeutics, Inc.'s SEC XBRL filings. Not investment advice.