Source: Protagonist Therapeutics, Inc.'s 10-K / 10-Q XBRL data on SEC EDGAR · fetched Nov 09, 2026
Revenue, net income & free cash flow
Income statement
fiscal years · USD
Fiscal year
FY2017
FY2018
FY2019
FY2020
FY2021
FY2022
FY2023
FY2024
FY2025
Revenue
$20.06M
$30.93M
$231.00K
$28.63M
$27.36M
$26.58M
$60.00M
$434.43M
$46.02M
Research & development
$46.18M
$59.50M
$65.00M
$74.51M
$126.01M
$126.22M
$120.16M
$138.13M
$159.29M
Operating income
-$37.90M
-$42.27M
-$80.52M
-$64.52M
-$125.84M
-$131.37M
-$93.65M
$252.84M
-$158.13M
Interest expense
—
—
$169.00K
$598.00K
—
—
—
—
—
Pre-tax income
-$36.96M
-$39.72M
-$77.88M
-$64.84M
-$125.55M
-$127.39M
-$78.95M
$279.41M
-$129.31M
Income tax
$0
-$799.00K
-$691.00K
$1.30M
$0
$0
$0
$4.22M
$838.00K
Net income
-$36.96M
-$38.92M
-$77.19M
-$66.15M
-$125.55M
-$127.39M
-$78.95M
$275.19M
-$130.15M
EBITDA
-$37.49M
-$41.74M
-$79.79M
-$63.57M
-$125.03M
-$130.34M
-$92.67M
$253.67M
-$156.85M
EPS (basic)
$-2.09
$-1.74
$-2.98
$-1.92
$-2.71
$-2.60
$-1.39
$4.47
$-2.05
EPS (diluted)
$-2.09
$-1.74
$-2.98
$-1.92
$-2.71
$-2.60
$-1.39
$4.23
$-2.05
Diluted shares
17.69M
22.36M
25.89M
34.40M
46.32M
49.04M
56.76M
65.08M
63.57M
Operating margin
-188.9%
-136.7%
-34857.6%
-225.4%
-460.0%
-494.2%
-156.1%
58.2%
-343.6%
Net margin
-184.2%
-125.9%
-33414.3%
-231.1%
-458.9%
-479.3%
-131.6%
63.3%
-282.8%
Balance sheet
fiscal years · USD
Fiscal year
FY2017
FY2018
FY2019
FY2020
FY2021
FY2022
FY2023
FY2024
FY2025
Cash & equivalents
$106.03M
$82.23M
$33.01M
$117.36M
$123.67M
$125.74M
$186.73M
$97.25M
$128.39M
Short-term investments
—
$46.62M
$100.01M
$188.45M
$203.24M
$111.61M
$154.89M
$321.66M
$438.97M
Total current assets
$150.95M
$137.50M
$145.31M
$315.61M
$340.74M
$243.08M
$355.58M
$591.64M
$577.57M
Total assets
$163.73M
$139.47M
$154.92M
$324.47M
$347.69M
$247.93M
$357.95M
$744.73M
$668.19M
Total current liabilities
$42.55M
$26.16M
$35.41M
$40.24M
$44.02M
$31.18M
$21.27M
$47.40M
$45.44M
Long-term debt
—
—
$9.79M
—
—
—
—
—
—
Total debt
—
—
$9.79M
—
—
—
—
—
—
Total liabilities
$43.10M
$26.96M
$74.95M
$44.86M
$47.67M
$32.32M
$21.27M
$69.43M
$53.48M
Shareholders' equity
$120.63M
$112.52M
$79.96M
$279.61M
$300.02M
$215.61M
$336.68M
$675.29M
$614.71M
Cash flow
fiscal years · USD
Fiscal year
FY2017
FY2018
FY2019
FY2020
FY2021
FY2022
FY2023
FY2024
FY2025
Operating cash flow
$3.87M
-$49.95M
-$41.53M
-$72.48M
-$107.86M
-$108.14M
-$70.24M
$184.15M
$57.67M
Capital expenditures
$666.00K
$486.00K
$967.00K
$471.00K
$1.10M
$795.00K
$609.00K
$1.35M
$1.59M
Free cash flow
$3.21M
-$50.43M
-$42.49M
-$72.95M
-$108.97M
-$108.93M
-$70.84M
$182.80M
$56.08M
Investing cash flow
$15.82M
$2.21M
-$53.71M
-$90.97M
-$15.86M
$91.47M
-$39.26M
-$299.48M
-$49.33M
Financing cash flow
$65.55M
$24.11M
$46.04M
$247.63M
$129.92M
$18.84M
$170.48M
$25.85M
$22.86M
Stock-based compensation
$4.24M
$6.92M
$8.35M
$7.90M
$16.39M
$24.20M
$29.29M
$37.55M
$45.97M
Depreciation & amortization
$406.00K
$527.00K
$732.00K
$948.00K
$813.00K
$1.03M
$977.00K
$826.00K
$1.28M
Income statement
quarters · USD
Quarter ended
Dec 2023
Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Mar 2026
Jun 2026
Sep 2026
Revenue
$60.00M
$254.95M
$4.17M
$4.67M
$170.64M
$28.32M
$5.55M
$4.71M
$7.44M
$56.37M
$213.47M
$274.41M
Cost of revenue
—
—
—
—
—
—
—
—
—
—
—
$1.10M
Gross profit
—
—
—
—
—
—
—
—
—
—
—
$273.31M
Research & development
$28.90M
$33.73M
$33.52M
$35.97M
$34.90M
$35.89M
$37.04M
$40.00M
$46.36M
$46.74M
$42.06M
$41.27M
Operating income
$23.05M
$206.31M
-$38.79M
-$41.45M
$126.78M
-$19.31M
-$42.04M
-$46.42M
-$50.35M
-$3.65M
$158.77M
$218.33M
Pre-tax income
$27.34M
$210.67M
-$31.29M
-$33.63M
$133.66M
-$11.65M
-$34.60M
-$39.34M
-$43.72M
$2.28M
$165.11M
$226.57M
Income tax
$0
$3.33M
-$676.00K
-$420.00K
$1.99M
$0
$172.00K
$0
$666.00K
-$1.50M
$2.27M
$6.56M
Net income
$27.34M
$207.34M
-$30.62M
-$33.21M
$131.67M
-$11.65M
-$34.77M
-$39.34M
-$44.38M
$3.78M
$162.85M
$220.01M
EBITDA
$23.30M
$206.54M
-$38.55M
-$41.22M
$126.90M
-$19.07M
-$41.74M
-$46.06M
-$49.98M
-$3.24M
$159.16M
$218.74M
EPS (basic)
$0.52
$3.41
$-0.50
$-0.54
$2.13
$-0.19
$-0.55
$-0.62
$-0.70
$0.06
$2.47
$3.32
EPS (diluted)
$0.52
$3.26
$-0.50
$-0.54
$2.01
$-0.19
$-0.55
$-0.62
$-0.70
$0.05
$2.29
$3.07
Diluted shares
—
63.60M
61.31M
61.77M
—
62.96M
63.51M
63.77M
—
70.49M
71.01M
71.73M
Gross margin
—
—
—
—
—
—
—
—
—
—
—
99.6%
Operating margin
38.4%
80.9%
-931.0%
-886.7%
74.3%
-68.2%
-758.0%
-985.2%
-677.1%
-6.5%
74.4%
79.6%
Net margin
45.6%
81.3%
-734.7%
-710.4%
77.2%
-41.2%
-627.0%
-834.9%
-596.8%
6.7%
76.3%
80.2%
Balance sheet
quarters · USD
Quarter ended
Dec 2023
Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Mar 2026
Jun 2026
Sep 2026
Cash & equivalents
$186.73M
$172.57M
$355.64M
$131.12M
$97.25M
$139.65M
$168.54M
$113.71M
$128.39M
$193.71M
$420.08M
$498.30M
Short-term investments
$154.89M
$150.07M
$208.35M
$337.60M
$321.66M
$434.71M
$401.92M
$462.40M
$438.97M
$354.07M
$362.50M
$301.77M
Total current assets
$355.58M
$627.55M
$570.92M
$476.77M
$591.64M
$605.86M
$602.53M
$586.42M
$577.57M
$613.46M
$807.15M
$1.10B
Total assets
$357.95M
$629.28M
$614.63M
$603.86M
$744.73M
$742.13M
$718.01M
$701.69M
$668.19M
$697.46M
$885.54M
$1.15B
Total current liabilities
$21.27M
$39.91M
$41.58M
$44.58M
$47.40M
$35.11M
$35.51M
$44.94M
$45.44M
$34.55M
$37.18M
$55.46M
Total liabilities
$21.27M
$68.83M
$73.31M
$71.94M
$69.43M
$53.08M
$49.99M
$56.25M
$53.48M
$41.99M
$44.00M
$61.64M
Shareholders' equity
$336.68M
$560.44M
$541.32M
$531.91M
$675.29M
$689.05M
$668.02M
$645.44M
$614.71M
$655.47M
$841.54M
$1.08B
Cash flow
quarters · USD
Quarter ended
Dec 2023
Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Mar 2026
Jun 2026
Sep 2026
Operating cash flow
$16.96M
-$27.43M
$268.62M
-$27.86M
-$29.18M
$125.36M
-$28.78M
-$1.94M
-$36.98M
-$48.94M
$219.05M
-$23.22M
Capital expenditures
$19.00K
$242.00K
$28.00K
$775.00K
$310.00K
$545.00K
$813.00K
$88.00K
$144.00K
$215.00K
$168.00K
$237.00K
Free cash flow
$16.94M
-$27.67M
$268.59M
-$28.64M
-$29.49M
$124.82M
-$29.59M
-$2.02M
-$37.12M
-$49.16M
$218.88M
-$23.46M
Investing cash flow
-$61.29M
$6.07M
-$88.12M
-$208.71M
-$8.72M
-$94.40M
$54.81M
-$58.55M
$48.81M
$90.89M
-$2.43M
$93.43M
Financing cash flow
$527.00K
$7.20M
$2.57M
$12.05M
$4.03M
$11.44M
$2.92M
$5.66M
$2.84M
$23.37M
$9.74M
$8.01M
Stock-based compensation
$6.60M
$9.35M
$8.94M
$10.16M
$9.09M
$13.80M
$10.91M
$10.56M
$10.70M
$14.52M
$14.04M
$14.36M
Depreciation & amortization
$248.00K
$236.00K
$241.00K
$231.00K
$118.00K
$239.00K
$304.00K
$361.00K
$376.00K
$407.00K
$397.00K
$409.00K
Quarterly figures are rebuilt from the year-to-date totals companies report — Q4 is the full year minus the first nine months, since no 10-Q is filed for it. Values are as filed; later restatements replace earlier ones. Fiscal years are labelled by the calendar year in which they end.